Background & Aims

Since the pathogenesis of fibromyalgia is unknown, treatment options are limited, ineffective and in fact based on symptom relief. Reserpine induces long-lasting muscle hyperalgesia and tactile allodynia and markedly decreases monoamine levels in the spinal cord and some regions of the brain. Lithium is widely used in treatment of bipolar disorder. Increasing evidences reported the neuroprotective effects of lithium against cell injuries caused by different noxious stimuli in cultured cells and animal model of neurodegenerative diseases. Therefore this study aims to provide an insight of new therapy for fibromyalgia. Objective: To investigate the effect of lithium treatment on pain in reserpine induced rat model of fibromyalgia

Methods

In the reserpine induced Wistar rat (n=8), different doses of lithium chloride (5, 10 and 15 mg/kg; i.p.), were administered on the days 1, 5, 7, 10 and 14 after the after 3rd day injection of reserpine. Control group received equal volume of normal saline. Pain threshold was determined by tail flick latency, acetone induced cold allodynia was measure by application of acetone with syringe fitted with a blunted needle at the centre of the plantar face of a hind paw. Tonic pain behaviour was measured by injecting 50µl s.c. injection of 2.5% formalin into the plantar surface of the right hind paw on only after 14 days of received lithium treatment

Results

Lithium treatment decreased nociceptive behavior in dose dependent manner whereas tonic pain rating was decreased at only higher dose of lithium treatment

Conclusions

Lithium treatment may useful for the treatment of fibromyalgia as it has shown to reduce nociceptive behavior in reserpine induced rat model of fibromyalgia.

References

NA

Presenting Author

Amrendra Jha

Poster Authors

Amrendra Jha

PhD

B.P.Koirala Institute of Health Sciences

Lead Author

Nirmala Limbu

MD

BP Koirala Institute of Health Sciences, Dharan, Nepal

Lead Author

GP Rauniyar

MD

BP Koirala Institute of Health Sciences, Dharan, Nepal

Lead Author

Topics

  • Models: Transition to Chronic Pain