Background & Aims
Children with orofacial cleft must undergo corrective invasive procedure, resulting in intense post-operative acute pain. Previous studies showed post-operative analgesic are often ineffective to manage this pain. The objective of this study was to evaluate the efficacy of curcumin as an analgesic agent in managing post-operative acute pain on children with orofacial cleft that went through a corrective procedure.
Methods
Fifty children aged between 3-36 months old who underwent a corrective procedure for their cleft lip and cleft palate at Unpad Dental Hospital, Bandung, Indonesia were recruited in this study. The pediatric patients were randomly assigned to the control group where standard analgesic was prescribed or to the intervention group where standard analgesic and curcumin patch were prescribed and applied. Pain measurement was performed by using the Face, Leg, Activity, Consolability and Cry (FLACC) scale and salivary Prostaglandin-E2 (PGE2) level measurement. All data were then gathered and compared by using the Wilcoxon-signed rank test.
Results
FLACC score in the intervention group has a significant (p<0.001) decrease from the mean value of 6.60 (SD=1.78) to 3.08 (SD=1.68). The PGE2 level within the intervention group also showed some decrease regardless of the insignificant (p=0.72) result. Yet, when compared to the control group, the PGE2 level did show a significant (p=0.01) difference.
Conclusions
It can be concluded that curcumin patch applied on post-operative children is a potentially effective adjuvant analgesic agent.
References
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Presenting Author
Tantry Maulina
Poster Authors
Topics
- Pain in Special Populations: Infants/Children