Background & Aims

CAPTURE is a 2-year, international, prospective, longitudinal study aiming to elevate the understanding of disease burden and treatment patterns among people living with migraine, stratified by headache frequency.

Methods

Approximately 2000 participants are planned to enrol in the study of which 163 participants are already enrolled in Canada. Adults with migraine diagnosed for >=1 year, aged <50 years at onset, and taking >=1 medication indicated for migraine with >=4 monthly headache days (MHDs) in the prior 3 months were assigned to cohorts based on headache frequency (cohort 1: 4-<8 MHDs; cohort 2: 8-<15 MHDs; cohort 3: >=15 MHDs; Figure). Descriptive data for baseline characteristics and patient-reported outcomes (PROs) (Migraine Disability Assessment [MIDAS], Migraine-Specific Quality of Life questionnaire v2.1 [MSQv2.1], Work Productivity and Activity Impairment Questionnaire [WPAI], Headache Impact Test-6, Patient Global Impression–Severity, Hospital Anxiety and Depression Scale, Migraine Interictal Burden Scale) are presented. Endpoints include durations of current/subsequent migraine treatment use and change from baseline of clinical outcomes (eg, MHDs, medication use, PROs).

Results

Among 239 participants (as of December 2023; cohort 1: n=68; cohort 2: n=104; cohort 3: n=67) (Table 1), baseline PROs indicated greater impairment and poorer quality of life with higher MHDs (Table 2). For cohorts 1, 2, and 3, respectively, baseline mean (SD) MIDAS total scores were 29 (40), 33 (30), and 61 (52); MSQv2.1 Role Function–Restrictive scores were 58.9 (17.5), 53.4 (20.8), and 44.8 (22.0); and WPAI migraine-related impairment was 39.4 (27.2), 40.6 (24.8), and 52.0 (22.8).

Conclusions

Baseline PROs suggest greater disease burden among participants with higher MHD frequency. CAPTURE will provide critical data on migraine disease patterns and the associated burden over time.

References

None

Presenting Author

May Ong

Poster Authors

May Ong

MD

University of British Columbia

Lead Author

E-mail

Topics

  • Epidemiology

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