Background & Aims

This case-control study’s objective was to investigate variables based on a cognitive-behavioral-emotional model related to the development of painful temporomandibular disorders (TMD) in a sample of monozygotic twins discordant for the condition.

Methods

20 monozygotic twins (10 pairs discordant for painful TMD), aged between 18 and 55 years, were studied. The diagnosis of painful TMD was determined according to the Diagnostic Criteria for Temporomandibular Disorders – Brazilian Portuguese (DC/TMD). The cognitive-behavioral-emotional variables analyzed were sociodemographic profile, pain sensitivity (pain threshold to pressure, allodynia, and hyperalgesia), oral behaviors, pain vigilance and awareness, pain catastrophizing, central sensitization, stress, anxiety, depression, alexithymia, mindfulness facets, sleep quality, pain control, pain intensity and interference, trigeminal and extratrigeminal pain areas.

Results

According to the adjusted regression model, there was an increased chance of TMD with: an increasing left-sided masseter face pain sensitivity score (OR=3.29;95%CI=(0.17-62.8),p=0.428); an increasing total pain catastrophizing score (OR=1.08; 95%CI=(0.64-1.8),p=0.776); an increasing score of difficulty in externalizing feelings (OR=1.61;95%CI=(0.13-2.9),p=0.539); and a scoring of the distraction facet of the FFMQ scale (OR=4.65;95%CI=(0.39-55.7),p=0.225).

Conclusions

From the cognitive-behavioral-emotional model studied in this case-control study of monozygotic twins discordant for painful TMD, painful sensitivity in the face, catastrophizing pain, difficulty in externalizing feelings, and the distraction facet (mindfulness) are variables that increase the chance of developing painful TMD.

References

1. Matsuka Y, Nagamatsu C, Itoh S, Tomonari T, Makki A, Minakuchi H, Maekawa K, Kanyama M, Kuboki T. Comparison of inter-twin concordance in symptoms of temporomandibular disorders: a preliminary investigation in an adolescent twin population. Cranio. 2007 Jan;25(1):23-9. doi: 10.1179/crn.2007.005.
2. Fillingim RB, Ohrbach R, Greenspan JD, Knott C, Diatchenko L, Dubner R, Bair E, Baraian C, Mack N, Slade GD, Maixner W. Psychological factors associated with development of TMD: the OPPERA prospective cohort study. J Pain. 2013 Dec;14(12 Suppl): T75-90. doi: 10.1016/j.jpain.2013.06.009.
3. Burri A, Lachance G, Williams F. A discordant monozygotic-twin approach to potential risk factors for chronic widespread pain in females. Twin Res Hum Genet. 2015 Apr;18(2):188-97. doi: 10.1017/thg.2015.7.
4. Bair E, Gaynor S, Slade GD, Ohrbach R, Fillingim RB, Greenspan JD, Dubner R, Smith SB, Diatchenko L, Maixner W. Identification of clusters of individuals relevant to temporomandibular disorders and other chronic pain conditions: the OPPERA study. Pain. 2016 Jun;157(6):1266-1278. doi: 10.1097/j.pain.0000000000000518.
5. Burri A, Ogata S, Rice D, Williams FMK. Twelve-year follow-up of chronic pain in twins: Changes in environmental and genetic influence over time. Eur J Pain. 2018 Sep;22(8):1439-1447. doi: 10.1002/ejp.1233.

Presenting Author

Laís Magri

Poster Authors

Lais Magri

PhD

Universidade de São Paulo

Lead Author

Melissa Melchior - MS

PhD Student

Lead Author

Graziela Da Silva - MS

Lead Author

Edilaine Gherardi-Donato - MS

PhD

Lead Author

Christie Leite-Panissi PhD

University of São Paulo

Lead Author

Topics

  • Specific Pain Conditions/Pain in Specific Populations: Orofacial Pain