Background & Aims

Chronic back pain is a public health issue associated with increasing socioeconomic burden worldwide, reduced quality of life, and disabling conditions (1,2). More than 50 % of patients with chronic back pain report insomnia (3), and patients with comorbid insomnia often report stronger and more widespread pain than those sleeping well(4). Given the effect of Melatonin on insomnia and the potential effect on pain, this systematic review aims to synthesize the evidence on the efficacy and safety of Melatonin in treating chronic back pain.

Methods

We are a conducting a systematic review on randomized controlled trials (RCTs) with meta-analyses adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (5). The protocol will be registered in an international registry for systematic reviews. The systematic literature search will use the PICO strategy to identify randomized clinical trials comparing the effect of Melatonin to placebo or other interventions. Outcomes includes pain, sleep, disability, quality of life, and analgesic use. Quality assessment of the included studies are performed according to the Cochrane risk-of-bias tool for randomized clinical trials.

Results

The data is being collected and analyzed and the final results will be presented at the conference.

Conclusions

The conclusions will be presented at the conference.

References

1. The Lancet Rheumatology. The global epidemic of low back pain. Lancet Rheumatol [Internet]. 2023;5(6):e305. Available from: https://dx.doi.org/10.1016/S2665-9913(23)00133-9
2. Ferreira ML, De Luca K, Haile LM, Steinmetz JD, Culbreth GT, Cross M, et al. Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5(6):e316–29.
3. Bahouq H, Allali F, Rkain H, Hmamouchi I, Hajjaj-Hassouni N. Prevalence and severity of insomnia in chronic low back pain patients. Rheumatol Int. 2013 May;33(5):1277–81.
4. Morin CM, Gibson D, Wade J. Self-reported sleep and mood disturbance in chronic pain patients. Clin J Pain. 1998 Dec;14(4):311–4.
5. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ [Internet]. 2021 Mar 29;372:n71. Available from: https://www.bmj.com/content/372/bmj.n71.abstract

Presenting Author

Kübra Kilic

Poster Authors

Kübra Kilic

MD

Pain Center, Department of Anesthesiology and Intensive Care Medicine, University Hospital Odense

Lead Author

E-mail

Bart Koes PhD

Erasmus MC

Lead Author

E-mail

Jonas Bloch Thorlund

Ph.D.

Department of Sports Science and Clinical Biomechanics, University of Southern Denmark

Lead Author

E-mail

Karin Due Bruun

MD

Pain Center,Department of Anesthesiology and Intensive Care, University Hospital Odense

Lead Author

E-mail

Henrik Bjarke Vaegter

University of Southern Denmark and University Hospital Odense, Denmark

Lead Author

E-mail

Topics

  • Specific Pain Conditions/Pain in Specific Populations: Low Back Pain