Background & Aims
Background:
The most common consequence of diabetes mellitus, diabetic peripheral neuropathy (DPN), has serious clinical implications that can affect patients’ quality of life. There is an urgent need to perform in-depth research to discover new methods because the medications now used for the prevention and treatment of DPN are partially effective and frequently have adverse effects.
Objective:
The objective of the study was to determine the effect of PRP injection on acupuncture points and pregabalin in painful diabetic poly neuropathy.
Methods
A randomized controlled trail was conducted at Iffat Anwar Medical Complex. All the clinically diagnosed patients having neuropathic sign and symptoms of DPN, with type 2 diabetes diagnosed having an HbA1c level greater than 7.5, both genders aged between 40 to 70 years were enrolled in the study. After the written and informed consent total of 60 patients were randomly divided into two groups in a 1:1 ratio. Group I received PRP injections on acupuncture points and Group II received standard treatment (75 mg pregabalin twice daily). The PRP injections treatment was given once a month till 3 months. Follow up of all patients was conducted every month till three months and after completion of treatment patients were followed after 1 year for final assessment. All the data was entered and analyzed by SPSS 25.0. The difference among pain, SF-36, Sleep quality scale among groups was compared by independent sample t test and before and after difference was observed by paired sample t-test.
Results
The VAS score significantly decreased in Group I from baseline to after treatment (Group I= 7.47+1.27 to 3.67+1.09, P-value<0.05) as compared to Group II (Group II=7.30+1.59 to 5.20+1.58, P-value<0.05). The Neuropathic symptoms scale also shows significant improvement (Group I= 13.50+50 to 8.50+2.30 Vs. Group II= 14.93+2.55 to 9.83+2.17, P-value<0.05), as well as the quality of life (Group I= 67.77 to 31.50+9.24 Vs. Group II=69.37+11.7to 41.20+12.16, P-value<0.05) and sleep quality scale (Group I=49.53+12.4 to 27.30+8.03 Vs. Group II= 52.13+10.9to 32.60+7.103, P-value<0.05).
Conclusions
It was concluded that the PRP injections treatment on acupuncture points significantly improved the complaint of pain, quality of sleep deprivation and neuropathic symptoms as compared to conventional treatment.
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Presenting Author
Shahzad Anwar
Poster Authors
Topics
- Specific Pain Conditions/Pain in Specific Populations: Neuropathic Pain - Peripheral