Background & Aims
Endometriosis is a chronic and debilitating disease associated with pelvic pain. Strategies have
been researched for pain control, such as the use of anti-inflammatory substances. In this
perspective, thalidomide appears as an option in pain control due to its immunomodulatory
property used in the treatment of various clinical conditions. The objective of this work was to
evaluate the analgesic and anti-inflammatory effect of thalidomide in the treatment of
experimental endometriosis.
Methods
36 Wistar rats were used and randomly separated into 06 groups:
CONTROL (-), LEUPROLIDE, SHAM and groups T25, T50 and T100 with oral administration
of 25, 50 and 100 mg/kg/day of thalidomide respectively. Behavioral tests were performed to
evaluate pain, evaluate serum levels of cytokines (INF ??, TNF ??, IL-6 and IL-10);
measurements of implant volumes before and at the end of the treatment protocol and
histopathological study of the implant areas.
Results
From a dose of 50mg/kg/day, a reduction in the pain threshold was observed in the behavioral tests applied. In the T50 and T100 groups, low levels of TNF ?? and IL6 were maintained in addition to a reduction in IL10 expression. Very similar levels of IFN-? were observed between the treated groups and the SHAM group. The T50, T100 and leuprolide groups obtained the least preservation of the ectopic epithelium, indicating a reduction in endometriotic implantation.
Conclusions
In the model studied, thalidomide had an
analgesic, anti-inflammatory action and reduced the size of the implants, more significantly
with doses starting at 50 mg/kg/day, and can be suggested as an option in the treatment of
endometriosis pain.
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12902015000300991&lng=en&nrm=iso. Acesso em: 8 maio 2021.
Presenting Author
João Batista Santos Garcia
Poster Authors
Isabela Bastos Jácome de Souza
Doutora
UFMA
Lead Author
Topics
- Assessment and Diagnosis